Sulfhemoglobinemia- The green blood in body
Sulfhemoglobinemia Introduction It is a rare condition in which there is excess sulfhemoglobin (sulfHb) in the blood. The pigment is a greenish derivative of hemoglobin which cannot be converted back to normal functional hemoglobin. It causes cyanosis even at low blood levels. It occurs when a sulfar atom is incorporated into the Hb molecule. When hydrogen sulfide (H2S) or sulfide ions and ferric ions combine in the blood, the blood is incapable of carrying oxygen . History In 1866, Hoppe- seyler observed the formation of a green product after reaching Hb-O2 with H2S and called this green derivatives sulfhemoglobin (SulfHb). Naturally occuring sulfHb is postulated to be derived from H2S produced by intestinal bacteria, but the mode of formation has not yet been elucidated. Sulf-Hb seldom exceeds 10% of the total Hb present. These sulfheme derivatives exhibit lower affinity towards O2 compared to the native proteins and cannot be reverted to the normal funct
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